Synthesis and antiviral activity of new substituted pyrimidine glycosides

…, E Hagag, AAH Abdel??Rahman

Index: Ramiz, Mahmoud M. M.; El-Sayed, Wael A.; Hagag, Ezzat; Abdel-Rahman, Adel A.-H. Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1028 - 1038

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Citation Number: 13

Abstract

Abstract A number of N-substituted pyrimidine glycosides were synthesized by coupling reaction of the pyrimidine base with acetobromosugars followed by deprotection. The synthesized compounds were tested for their antiviral activity against Hepatitis B Virus (HBV). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high anti viral ...

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