Tetrahedron Letters

Efficient synthesis of 2-aryl-6-methyl-2, 3-dihydro-1H-pyridin-4-ones

O Renault, J Guillon, P Dallemagne, S Rault

Index: Renault, Olivier; Guillon, Jean; Dallemagne, Patrick; Rault, Sylvain Tetrahedron Letters, 2000 , vol. 41, # 5 p. 681 - 683

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Citation Number: 17

Abstract

Syntheses of 2-aryl-6-methyl-2, 3-dihydro-1H-pyridin-4-ones were achieved starting from corresponding β-aryl-β-amino acids. This reaction sequence involved, as a key step, the condensation of an acid chloride with a diketone using SmI3 as catalyst. A final intramolecular cyclization furnished the attempted product.