Organic letters

Preparation of polyfunctional zinc organometallics using an Fe-or Co-catalyzed Cl/Zn-exchange

L Melzig, CR Diène, CJ Rohbogner, P Knochel

Index: Bluemke, Tobias D.; Piller, Fabian M.; Knochel, Paul Chemical Communications, 2010 , vol. 46, # 23 p. 4082 - 4084

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Citation Number: 8

Abstract

A new Fe-or Co-catalyzed Cl/Zn-exchange reaction allows the direct transformation of aryl, heteroaryl, and also alkyl chlorides into the corresponding zinc reagents. The method tolerates functional groups such as a nitrile or an ester. Remarkably, secondary and tertiary