Antiplatelet properties of novel N-substituted-phenyl-1, 2, 3-triazole-4-acylhydrazone derivatives

…, JM Figueiredo, JLM Tributino, ALP Miranda…

Index: Cunha, Anna C.; Figueiredo, Juliana M.; Tributino, Jorge L. M.; Miranda, Ana L. P.; Castro, Helena C.; Zingali, Russolina B.; Fraga, Carlos A. M.; De Souza, Maria Cecilia B. V.; Ferreira, Vitor F.; Barreiro, Eliezer J. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 9 p. 2051 - 2059

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Citation Number: 162

Abstract

This paper describes the design, synthesis and pharmacological evaluation of new N- acylhydrazone (NAH) compounds, belonging to the N-substituted-phenyl-1, 2, 3-triazole-4- acylhydrazone class (2a–p). Classical heteroaromatic ring bioisosterism strategies were applied to the previously reported N-phenylpyrazolyl-4-acylhydrazone derivative 1, elected as lead-compound due to its important anti-aggregating profile on arachidonic acid ...