Antineoplastic Agents. 445. Synthesis and evaluation of structural modifications of (Z)-and (E)-Combretastatin A-4 1

…, MR Rhodes, DL Herald, E Hamel…

Index: Pettit, George R.; Rhodes, Monte R.; Herald, Delbert L.; Hamel, Ernest; Schmidt, Jean M.; Pettit, Robin K. Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 4087 - 4099

Full Text: HTML

Citation Number: 115

Abstract

A series of cis-and trans-stilbenes related to combretastatin A-4 (1a), with a variety of substituents at the 3'-position of the aryl B-ring, were synthesized and evaluated for inhibitory activity employing six human cancer cell lines (NCI-H460 lung carcinoma, BXPC-3 pancreas, SK-N-SH neuroblastoma, SW1736 thyroid, DU-145 prostate, and FADU pharynx- squamous sarcoma) as well as the P-388 murine lymphocyte leukemia cell line. Several ...