Stieglitz rearrangement of N, N-dichloro-β, β-disubstituted taurines under mild aqueous conditions

TP Shiau, A Houchin, S Nair, P Xu, E Low…

Index: Shiau, Timothy P.; Houchin, Ashley; Nair, Satheesh; Xu, Ping; Low, Eddy; Najafi, Ramin (Ron); Jain, Rakesh Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1110 - 1114

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Citation Number: 14

Abstract

New topical anti-infectives comprised of N, N-dichloro-β, β-disubstituted taurines [Tetrahedron Lett. 2008, 49, 2193; Biorg. Med. Chem. Lett. 2009, 19, 196] have been examined for structure–stability relationships (SSR) based upon various alkyl, heteroalkyl and cycloalkyl β-substitutions. These substitutions affect order-of-magnitude changes in the aqueous stability of these N, N-dichloroamines which can undergo Stieglitz ...