Carbohydrate research

Synthesis of 5′-O-β-d-glucopyranosyl and 5′-O-β-d-galactopyranosyl derivatives of ribavirin

NB Hanna, RK Robins, GR Revankar

Index: Hanna, Naeem B.; Robins, Roland K.; Revankar, Ganapathi R. Carbohydrate Research, 1987 , vol. 165, p. 267 - 274

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Citation Number: 6

Abstract

Abstract The synthesis of 5′-O-β-d-glucopyranosyl and 5′-O-β-d-galactopyranosyl derivatives (13 and 15, respectively) of the antiviral agent ribavirin are descrobed. Direct glycosylation of 2′, 3′-O-isopropylideneribavirin with either tetra-O-acetyl-α-d- glucopyranosyl bromide (4) or tetra-O-acetyl-α-d-galactopyranosyl bromide (8) under Koenigs-Knorr conditions (ie., silver carbonate, silver perchlorate, and Drierite in ...