Azido carbonyl compounds as DNA cleaving agents

N Chowdhury, S Dutta, S Karthick, A Anoop…

Index: Chowdhury, Nilanjana; Dutta, Sansa; Karthick; Anoop, Anakuthil; Dasgupta, Swagata; Pradeep Singh Journal of Photochemistry and Photobiology B: Biology, 2012 , vol. 115, p. 25 - 34

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Abstract

Irradiation of azido carbonyl compounds using UV light (⩾ 310nm) produced triplet alkyl nitrenes and aroyl radicals, which resulted in efficient cleavage of single strand DNA at pH 7.0. DNA cleaving ability of azido carbonyl compounds was found to be dependent on its concentration and substituents on its aromatic ring. Further, newly synthesized naphthalene based azido carbonyl compounds showed DNA cleavage ability at longer wavelength of ...