Synthesis and biological evaluation of 3-ethylidene-1, 3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors

NH Lin, P Xia, P Kovar, C Park, Z Chen, H Zhang…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 2 p. 421 - 426

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Citation Number: 44

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 31, 32, 33 and 34 To continue our search for a structurally different Chk1 inhibitor that possesses potent activity against Chk1 enzyme, we initiated an extensive medicinal chemistry effort based on high throughput screen hits. ...