Molecular basis for bleomycin amplification: conformational and stereoelectronic effects in unfused amplifiers

L Strekowski, JL Mokrosz, FA Tanious…

Index: Strekowski, Lucjan; Mokrosz, Jerzy L.; Tanious, Farial A.; Watson, Rebecca A.; Harden, Donald; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1231 - 1240

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Citation Number: 35

Abstract

Sixteen unfused heterobiaromatic and biphenyl compounds substituted with an amino side chain (protonated in water) have been tested for (i) binding with DNA and (ii) their effect on the digestion of the DNA double helix by a bleomycin-iron complex. Only the DNA intercalating molecules amplify the digestion of DNA. One 2, 2'-bipyridine derivative tested is an inhibitor of the bleomycin reaction because it removes ferrous ion from the bleomycin ...