The Journal of Organic Chemistry

Synthesis of new amino acids mimicking sulfated and phosphorylated tyrosine residues

I Marseigne, BP Roques

Index: Marseigne, I.; Roques, B. P. Journal of Organic Chemistry, 1988 , vol. 53, # 15 p. 3621 - 3624

Full Text: HTML

Citation Number: 88

Abstract

The presence of a sulfated tyrosine residue was first detected in fibrinopeptide B,'then on fibrinogens, 2 gastrin? and chole~ ystokinin,~ and more recently in several secretory proteins such as immunoglobin G5 and fibronectin! and in an insect neuropeptide designated leuco-~ ulfakinin.~ Presumably, the 0-sulfate ester group is introduced at a posttranslational stage of the biosynthesis but very little is known about the enzyme (s) ...