Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1, 4-dihydropyridines

CE Sunkel, M Fau de Casa-Juana…

Index: Sunkel; Fau de Casa-Juana; Javier Cillero; Priego; Ortega Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1886 - 1890

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Citation Number: 42

Abstract

A series of l, 4-dihydropyridines (DHP) bound to 1, 2-benzisothiazol-3-ones were synthesized and evaluated for their ability to inhibit platelet aggregation induced by collagen in human platelet-rich plasma (PRP) and to protect mice against experimental thrombosis. The results showed that the compounds were in vitro inhibitors of collagen-induced platelet aggregation. Most of them were also effective in reducing mortality in the mouse ...