Chemical conversion of L-. ALPHA.,. OMEGA.-diamino acids to L-. OMEGA.-carbamoyl-. ALPHA.-amino acids by ruthenium tetroxide oxidation.

S Yoshifuji, KENI TANAKA, Y NITTA

Index: Yoshifuji, Shigeyuki; Tanaka, Ken-ichi; Nitta, Yoshihiro Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 7 p. 2994 - 3001

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Citation Number: 20

Abstract

Ruthenium tetroxide oxidation of N, C-protected derivatives of L-2, 4-diaminobutyric acid, L- ornithine and L-lysine was carried out under two-phase conditions and the corresponding imides, formed through the oxidation of the methylene adjacent to the ω-amino group, were obtained in good yields. Removal of the protecting groups from the products gave L- asparagine, L-glutamine and L-2-aminoadipic acid 6-amide, respectively. Thus, the first ...

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