Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents

D Edmont, R Rocher, C Plisson, J Chenault

Index: Edmont, Dolores; Rocher, Richard; Plisson, Christophe; Chenault, Jacques Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1831 - 1834

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Citation Number: 93

Abstract

The number of people suffering from diabetes around the world increases day by day. Predictions estimate from 110 million in 1994, numbers will reach 300 million in 2025. 1 About 90% of cases are diabetes of type II (NIDDM), and recent therapies to treat this type of diabetes require the use of oral hypoglycaemic drugs. Amongst the different hypoglycaemic drugs in force at present, guanidine derivatives 2 are often prescribed, the most well known being metformin.