Tetrahedron Letters

An expedient atom-efficient synthesis of the cannabinoid CB 1 receptor inverse agonist ibipinabant

JHM Lange, HJ Sanders, J van Rheenen

Index: Lange, Jos H.M.; Sanders, Hans J.; Van Rheenen, Jeroen Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1303 - 1305

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Abstract

A novel synthetic route to the highly selective and orally active cannabinoid CB1 receptor inverse agonist ibipinabant is described which combines the use of inexpensive, commercially available reagents and mild reaction conditions with a high degree of atom- efficiency. The method is expected to enable the rapid synthesis of a variety of sulfonylguanidines.