Synthesis of a New Series of Enkaphalin Related Galactosyl Conjugates

…, F Reig, A Parente, JM Garcia??Anton

Index: Vansteenkiste, Stefan; Schacht, Etienne; Haro, Isabel; Reig, Francesca; Parente, Antonio; Garcia-Anton, Jose Maria Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 10 p. 759 - 766

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Citation Number: 4

Abstract

Abstract (D-Met 2, Pro 5)-enkephalin-N-(β-D-galactopyranosyl) amide, a glycopeptide containing a galactose residue at the C-terminal position of the μ-selective enkaphalin analogue (D-Met 2, Pro 5)-enkaphalinamide, has been synthesized by the liquid phase procedure according to different strategies. Such analogue exhibited a great antinociceptive potency after intracerebroventricular injection in the “in vivo” tail immersion test when ...