A 13-Oxo-9, 10-epoxytridecenoate Phospholipid Analogue of the Genotoxic 4, 5-Epoxy-2 E-decenal: Detection in Vivo, Chemical Synthesis, and Adduction with DNA

C Mesaros, BG Gugiu, R Zhou, SH Lee…

Index: Mesaros, Clementina; Gugiu, Bogdan G.; Zhou, Rong; Lee, Seon Hwa; Choi, Jaewoo; Laird, James; Blair, Ian A.; Salomon, Robert G. Chemical Research in Toxicology, 2010 , vol. 23, # 3 p. 516 - 527

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Citation Number: 4

Abstract

Often guided by analogy with nonphospholipid products from oxidative cleavage of polyunsaturated fatty acids, we previously identified a variety of biologically active oxidatively truncated phospholipids. Previously, 4, 5-epoxy-2 (E)-decenal (4, 5-EDE) was found to be produced by oxidative cleavage of 13-(S)-hydroperoxy-9, 11-(Z, E)-octadeca- dienoic acid (13-HPODE). 4, 5-EDE reacts with deoxy-adenosine (dAdo) and deoxy- ...