Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2, 3-bis (hydroxyphenyl) butanes and 2, 3-bis (hydroxyphenyl) but-2-enes
RW Hartmann, A Heindl, MR Schneider…
Index: Hartmann, Rolf W.; Heindl, Alexander; Schneider, Martin R.; Schoenenberger, Helmut Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 322 - 328
Full Text: HTML
Citation Number: 15
Abstract
(TiCl,/Zn/pyridine) of the methoxy-substituted a, a, a-trifluoroacetophenones, separation of the resulting cis-and trans-stilbene derivatives, and ether cleavage with BBr3. The cis- stilbenes were catalytically hydrogenated to give meso-1, 1, 1, 4, 4, 4-hexafluoro-2, 3-bis (4- and 3-hydroxypheny1) butanes 6 and 8. Compounds 2, 4, 6, and 8 showed 2-to 10-fold increased binding affinities for the estradiol receptor (E2R) and enhanced estrogenicity in ...
Related Articles:
[Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486]
Surface modification of nylon 6, 6 using a carbene insertion approach
[Blencowe, Anton; Cosstick, Kevin; Hayes, Wayne New Journal of Chemistry, 2006 , vol. 30, # 1 p. 53 - 58]
Acyclic amides as estrogen receptor ligands: synthesis, binding, activity and receptor interaction
[Stauffer, Shaun R.; Sun, Jun; Katzenellenbogen, Benita S.; Katzenellenbogen, John A. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 6 p. 1293 - 1316]
Design and synthesis of a tag??free chemical probe for photoaffinity labeling
[Mayer, Timo; Maier, Martin E. European Journal of Organic Chemistry, 2007 , # 28 p. 4711 - 4720]
[Kakino; Shimizu; Yamamoto Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 2 p. 371 - 376]