Enantioselective liquid–liquid extraction of (R, S)-phenylglycinol using a bisnaphthyl phosphoric acid derivative as chiral extractant

…, BJV Verkuijl, J Bokhove, AJ Minnaard, JG de Vries…

Index: Schuur, Boelo; Verkuijl, Bastiaan J.V.; Bokhove, Jeroen; Minnaard, Adriaan J.; De Vries, Johannes G.; Heeres, Hero J.; Feringa, Ben L. Tetrahedron, 2011 , vol. 67, # 2 p. 462 - 470

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Citation Number: 22

Abstract

This study demonstrates that enantioseparation by liquid–liquid extraction can be done in a continuous flow mode on both laboratory and industrial scale and is a promising technique that could become a competitive alternative for crystallization or chromatographic approaches. We studied the enantioselective liquid–liquid extraction of phenylglycinol (Pgl) using a bisnaphthyl phosphoric acid extractant. Batch experiments were performed to ...