Influence of 4-or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl) sulfonyl] isatin derivatives on their inhibitory activities towards caspases-3 …

P Limpachayaporn, B Riemann, K Kopka…

Index: Limpachayaporn, Panupun; Riemann, Burkhard; Kopka, Klaus; Schober, Otmar; Schaefers, Michael; Haufe, Guenter European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 562 - 578

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Citation Number: 6

Abstract

A series of new 4-or 5-substituted pyrrolidine derivatives of 5-[1-(2- methoxymethylpyrrolidinyl) sulfonyl] isatin bearing additional n-butyl or 4-fluorobutyl groups at the isatin nitrogen were prepared and their inhibitory activities have been tested against caspases-3 and-7, which are known to participate in the execution of the programmed cell death, called apoptosis. Several analogues fluorinated at the 4-position of the pyrrolidine ...