Tetrahedron Letters

Microwave-assisted synthesis of tetrahydroindoles

L Piras, C Ghiron, G Minetto, M Taddei

Index: Piras, Leonarda; Ghiron, Chiara; Minetto, Giacomo; Taddei, Maurizio Tetrahedron Letters, 2008 , vol. 49, # 3 p. 459 - 462

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Citation Number: 12

Abstract

An efficient synthesis of tetrahydroindoles with different substituents in position 1 is described. Microwave-assisted aminolysis of 4-oxo-4, 5, 6, 7-tetrahydrobenzofuran with different primary amines gives the corresponding tetrahydroindoles in few minutes. All attempts to use microwave dielectric heating to reduce the time required for preparation of 4- oxo-4, 5, 6, 7-tetrahydrobenzofuran, starting from 1, 3-cyclohexandione were on the other ...