A scalable synthesis of a histamine H3 receptor antagonist

NS Mani, JA Jablonowski, TK Jones

Index: Mani, Neelakandha S.; Jablonowski, Jill A.; Jones, Todd K. Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8115 - 8117

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Citation Number: 24

Abstract

The third histamine (H 3 ) receptor was first described as a presynaptic autoreceptor located in the central nervous system. 1 Subsequently, H 3 receptors were also shown to be located presynaptically as heteroreceptors on nonhistamine-containing neurons. 2 A number of potential therapies for disorders associated with sleep−wake cycle, cognition, memory, food intake, and thermoregulation using modulators of H 3 receptors have been proposed on the basis of ...