Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr

…, A Tasker, L Wang, M Zhang, A Coxon, J Bready…

Index: Dominguez, Celia; Smith, Leon; Huang, Qi; Yuan, Chester; Ouyang, Xiaohu; Cai, Lynn; Chen, Paul; Kim, Joseph; Harvey, Timothy; Syed, Rashid; Kim, Tae-Seong; Tasker, Andrew; Wang, Ling; Zhang, Michael; Coxon, Angela; Bready, James; Starnes, Charles; Chen, Danlin; Gan, Yongmei; Neervannan, Sesha; Kumar, Gondi; Polverino, Anthony; Kendall, Richard Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 6003 - 6008

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Citation Number: 19

Abstract

Inhibition of tumor-induced angiogenesis is a promising strategy in anticancer research. Neovascularization is a process required for both tumor growth and metastasis. Enhanced understanding of the underlying molecular mechanisms has led to the discovery of a variety of pharmaceutically attractive targets. Decades of investigation suggest that vascular endothelial growth factor (VEGF) and its receptors, in particular VEGFR2 or kinase insert- ...