A new family of potential oncostatics: 2-chloroethylnitrososulfamides (CENS)—I. Synthesis, structure, and pharmacological evaluation (preliminary results)

M Abdaoui, G Dewynter, N Aouf, G Favre…

Index: Abdaoui, Mohamed; Dewynter, Georges; Aouf, Nourredine; Favre, Gilles; Morere, Alain; Montero, Jean-Louis Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 8 p. 1227 - 1235

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Citation Number: 34

Abstract

A new series of alkylating agents, 2-chloroethylnitrososulfamides (CENS), were developed on the model of 2-chloroethylnitrosoureas. Starting from chlorosulfonyl isocyanate, a four- step synthesis (carbamoylation-sulfamoylation, Mitsunobu alkylation, deprotection, and nitrosation) gives the title compounds in a 47–58% overall yield. The selection of the nitrosation site can be directed through an alternative route. The pharmacological ...