Synthesis

Synthesis of isoxazole-5-carboxylates by cyclization of oxime 1, 4-dianions with diethyl oxalate

TT Dang, U Albrecht, P Langer

Index: Synthesis, , # 15 p. 2515 - 2522

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Citation Number: 13

Abstract

... Ketol 3a was transformed into isoxazole 4a by treatment with p-toluenesulfonic acid (toluene, reflux). [11]. ... Scheme 1 Synthesis of isoxazoles 4a-k. Reagents and conditions: (i) 1. n-BuLi (2.5 equiv), -78 °C, 45 min; 2. rt, 15 min; 3. 2, -78 °C to rt, 16 h; (ii) TsOH·H 2 O (5.0 equiv ...

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