Towards a biomimetic poly-aminoketone foldamer: synthesis of a triply protected monomer and its coupling to a dimer, trimer and tetramer
R Barbe, J Hasserodt
Index: Barbe, Romain; Hasserodt, Jens Tetrahedron, 2007 , vol. 63, # 10 p. 2199 - 2207
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Citation Number: 5
Abstract
The design of a new biomimetic foldamer, relying on the weak amine–carbonyl interaction for secondary structure formation, is presented. The efficient synthesis of a triply protected monomer starting from glycidol was developed. This monomer contains a dioxolane- protected keto group that will allow liberation of the ketone functionality in the backbone once construction of the oligomeric backbone is complete. This monomer contains two ...
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