Highly regioselective hydrogenolysis of bis (α-methylbenzyl) amine derivatives affected by the trifluoromethyl substituent on the aromatic ring
…, K Inomiya, Y Katsuhara, K Higashiyama, A Ishii
Index: Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro Organic Letters, 2003 , vol. 5, # 7 p. 1007 - 1010
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Citation Number: 35
Abstract
The highly regioselective hydrogenolysis of bis (α-methylbenzyl) amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted α-phenylethylamines.
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