A practical synthesis of the dual matrix metalloprotease/tumor necrosis factor inhibitor MMP090
JS Slade, JA Vivelo, DJ Parker, J Bajwa…
Index: Organic Process Research and Development, , vol. 9, # 5 p. 608 - 620
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Abstract
... Organic Process Research & Development. ... The original process was modified in that the sulfonyl chloride was added slowly to a hot (78 °C) solution of the substrate ... This addition-controlled procedure allowed for moderation of the gas evolution as well as the heat of the reaction ...
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