Synthesis

Pyrido [2, 3-d] pyrimidine Derivatives: Synthesis via the Intermolecular Aza-Wittig Reaction/Heterocyclization and the Crystal Structure

T Okawa, M Toda, S Eguchi, A Kakehi

Index: Okawa, Tomohiro; Toda, Mieko; Eguchi, Shoji; Kakehi, Akikazu Synthesis, 1998 , # 10 p. 1467 - 1475

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Citation Number: 21

Abstract

Abstract: Pyrido [2, 3-d] pyrimidine derivatives 5 were synthesized by the intermolecular aza- Wittig reaction of 2-(triphenylphosphoranylidene) aminonicotinamides 3 derived from 2- aminonicotinic acid (1), with carboxylic acid chloride followed by heterocyclization via imidoyl chloride intermediate 4. The structure of 3-allyl-2-(4-nitrophenyl)-4 (3H)-pyrido [2, 3- d] pyrimidinone (5b) was established by X-ray crystallographic analysis. This methodology ...