Organic letters

Copper (II) carboxylate-promoted intramolecular carboamination of alkenes for the synthesis of polycyclic lactams

PH Fuller, SR Chemler

Index: Fuller, Peter H.; Chemler, Sherry R. Organic Letters, 2007 , vol. 9, # 26 p. 5477 - 5480

Full Text: HTML

Citation Number: 57

Abstract

The copper (II) carboxylate-promoted intramolecular carboamination reactions of variously substituted γ-alkenyl amides have been investigated. These oxidative cyclization reactions efficiently provide polycyclic lactams, useful intermediates in nitrogen heterocycle synthesis, in good to excellent yields. The efficiency of the carboamination process is dependent upon the structure of the amide backbone as well as the nitrogen substituent.