Anthranilic acid based CCK 1 antagonists: the 2-indole moiety may represent a “needle” according to the recent homonymous concept

A Varnavas, L Lassiani, V Valenta, F Berti…

Index: Varnavas, Antonio; Lassiani, Lucia; Valenta, Valentina; Berti, Federico; Tontini, Andrea; Mennuni, Laura; Makovec, Francesco European Journal of Medicinal Chemistry, 2004 , vol. 39, # 1 p. 85 - 97

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Citation Number: 24

Abstract

Recently we described an innovative class of non-peptide CCK1 antagonists keeping appropriate pharmacophoric groups on the anthranilic acid employed as a molecular scaffold. The lead compound obtained, VL-0395, characterized by the presence of Phe and the 2-indole moiety at the C-and N-termini of anthranilic acid, respectively, is endowed with submicromolar affinity towards CCK1 receptors. Thus, we have prepared and tested on ...