Pharmaceutical Chemistry Journal

Synthesis of 2-methyl-4-amino-5-tert-butoxymethylpyrimidine and splitting of its ether bond

MM Litvak

Index: Litvak, M. M. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 11 p. 935 - 938 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 11 p. 1374 - 1377

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Abstract

When compound VII was treated with a 25% solution of HCI in 2-butanol (this solvent was chosen because it is used for the industrial synthesis of III) at 20~ the ether bond was split more slowly: after 24 h, the presence of the tert-butyl group was still noted in the sample.