4-(6-Methoxy-2-naphthyl) butan-2-one and related analogs, a novel structural class of antiinflammatory compounds
AC Goudie, LM Gaster, AW Lake, CJ Rose…
Index: Goudie,A.C. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, # 12 p. 1260 - 1264
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Citation Number: 49
Abstract
. A series of compounds related to 4-(6-methoxy-2-naphthyl) butan-2-one has been prepared and tested for antiinflammatory activity by the cotton pellet granuloma method. Compounds possessing a small lipophilic group such as methoxyl, methyl, or chloro in the 6 position in conjunction with a butan-% one side chain in the 2 position of the naphthalene ring were most active. The introduction of a methyl group along the side chain was ...
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