Straightforward homochiral synthesis of the lactone moiety of mevinic acids

…, IM McFarlane, CG Newton, P Pitchen, M Webster

Index: France, Christopher J.; McFarlane, Ian M.; Newton, Christopher G.; Pitchen, Philippe; Webster, Michael Tetrahedron Letters, 1993 , vol. 34, # 10 p. 1635 - 1638

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Citation Number: 13

Abstract

Abstract A new straightforward synthesis of the common lactone moiety of mevinic acids is described starting from tri-O-acetyl-D-glucal 2. The key diastereoselective O-glycosidation of 2 with methanol and subsequent methanolysis and tritylation are incorporated in a simple and efficient one-pot process.