Enzymic control of stereochemistry among the Thalictrum bisbenzylisoquinoline alkaloids

H Guinaudeau, AJ Freyer, M Shamma, KHC Başer

Index: Guinaudeau, Helene; Freyer, Alan J.; Shamma, Maurice; Baser, Kemal Husnu Can Tetrahedron, 1984 , vol. 40, # 11 p. 1975 - 1982

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Citation Number: 8

Abstract

The new bisbenzylisoquinolines (+)-tha1igrisine 1 and (+)-tha1iphylline (6) have been isolated from Thalictrum minus var. microphyllum. Four rules are described which correlate the structures of Thalictrum bisbenzylisoquinolines with their stereochemistry at C-1 and C- 1'. As a result,(+)-tha1rugosamine is shown to be identical with (+)-homoaromo1ine (14).(+)- Thalisamine and (+)-N'-norhernandezine are also identical and are represented by ...