Preparation and biodistribution of [18 F] FP2OP as myocardial perfusion imaging agent for positron emission tomography

T Mou, H Jing, W Yang, W Fang, C Peng, F Guo…

Index: Mou, Tiantian; Jing, Huihui; Yang, Wenjiang; Fang, Wei; Peng, Cheng; Guo, Feng; Zhang, Xianzhong; Pang, Yan; Ma, Yunchuan Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1312 - 1320

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Citation Number: 25

Abstract

Myocardial extractions of pyridaben, a mitochondrial complex I (MC-I) inhibitor, is well correlated with blood flow. Based on the synthesis and characterization of pyridaben analogue 2-tert-butyl-5-[2-(2-[18F] fluroethoxy) ethoxy] benzyloxy]-4-chloro-2H-pyridazin-3- one ([18F] FP2OP), this study assessed its potential to be developed as myocardial perfusion imaging (MPI) agent. Methods: The tosylate labeling precursor 2-(2-(4-(tert-butyl ...