Molecules

Synthesis and anticancer activity of di (3-thienyl) methanol and di (3-thienyl) methane

…, HS Kim, YJ Chae, YN Lee, GC Kwon, EH Choi, IT Kim

Index: Kaushik, Nagendra Kumar; Kim, Hong Seon; Chae, Young June; Lee, Young Nam; Kwon, Gi-Chung; Choi, Eun Ha; Kim, In Tae Molecules, 2012 , vol. 17, # 10 p. 11456 - 11468

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Citation Number: 15

Abstract

Abstract: Di (3-thienyl) methanol (2) and di (3-thienyl) methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and ...

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