Synthesis of 2, 3-bis (halomethyl) quinoxaline derivatives and evaluation of their antibacterial and antifungal activities

H Ishikawa, T Sugiyama, A Yokoyama

Index: Ishikawa, Hisato; Sugiyama, Takayuki; Yokoyama, Akihiro Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 4 p. 438 - 444

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Citation Number: 8

Abstract

Quinoxaline derivatives having bis (fluoromethyl), bis (chloromethyl), or bis (iodomethyl) groups at the 2-and 3-positions, and various electron-donating/withdrawing substituents at the 6-and/or 7-positions, were synthesized. Their antibacterial and antifungal activities were evaluated by means of minimum inhibitory concentration assays. The relationships between the substituents and the antimicrobial activities of the quinoxaline derivatives indicate that ...