Synthesis and evaluation of anti-tubercular activity of 6-(4-substitutedpiperazin-1-yl) phenanthridine analogues

…, B Arun, JP Sridevi, D Sriram, P Yogeeswari…

Index: Nagesh, Hunsur Nagendra; Suresh, Narva; Mahalakshmi Naidu, Kalaga; Arun, Boyineni; Padma Sridevi, Jonnalagadda; Sriram, Dharmarajan; Yogeeswari, Perumal; Sekhar, Kondapalli Venkata Gowri Chandra European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 333 - 339

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Citation Number: 16

Abstract

Abstract A series of seventeen new 6-(4-substitutedpiperazin-1-yl) phenanthridine derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H 37 Rv by Microplate Alamar Blue Assay and most active compounds were tested for cytotoxicity studies against mouse macrophage cell lines (RAW264. 7). Among the tested compounds, ten compounds exhibited significant activity ...