Catalytic hydrogen atom transfer (HAT) for sustainable and diastereoselective radical reduction

A Gansäuer, M Klatte, GM Brändle…

Index: Gansaeuer, Andreas; Klatte, Max; Braendle, Gerhard M.; Friedrich, Joachim Angewandte Chemie - International Edition, 2012 , vol. 51, # 35 p. 8891 - 8894

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Citation Number: 30

Abstract

Radical reduction by HAT (hydrogen atom transfer) is an essential step in numerous radical reactions.[1] While transition-metal hydrides are in principle excellent reagents for this purpose because of their low bond dissociation energies,[2] their use in such reactions is attractive only when they serve as catalysts.[2d] The ideal catalyst for such a process should be able to activate a readily available, nontoxic terminal reductant to form the transition- ...