Facile syntheses of bioactive 5-arylidenethiobarbituric acids

A Sharif, E Ahmed, MA Munawar, S Jabeen…

Index: Sharif, Ahsan; Ahmed, Ejaz; Munawar, Munawar Ali; Jabeen, Shamsa; Khan, Misbah-Ul-Ain; Begum, Robina; Farrukh, Aleeza; Ashraf, Muhammad; Arshad, Shafia; Afza, Nighat Journal of the Chemical Society of Pakistan, 2011 , vol. 33, # 4 p. 578 - 586

Full Text: HTML

Citation Number: 5

Abstract

A simple and green chemistry route for the preparation of 5-arylidenethiobarbituric acids has been developed by Knoevenagel condensation of thiobarbituric acid with different aromatic and heteroaromatic aldehydes using catalytic amount of acetic acid by grinding in mortar and pestle. The title compounds were obtained in good to high yields (50-89%) and characterized by IR, NMR, mass spectroscopy and elemental analysis. All compounds ...