Synthetic communications

Syntheses of 4??[(1H, 3H)??Pyrimidine??2, 4??Dion??1??yl]??and 4??[(1H, 3H)??5??Methylpyrimidine??2, 4??Dion??1??yl]??1, 6??Heptadienes

KH Bouhadir, JL Zhou, PB Shevlin

Index: Bouhadir, Kamal H.; Zhou, Jing-Lan; Shevlin, Philip B. Synthetic Communications, 2005 , vol. 35, # 7 p. 1003 - 1010

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Citation Number: 10

Abstract

Abstract Heptadienes containing nucleic bases are attractive building blocks for the synthesis of carbocyclic oligonucleotide analogs. Herein, we report an alternative synthetic route to 4??[(1H, 3H)??pyrimidine??2, 4??dion??1??yl]??1, 6??heptadiene and 4??[(1H, 3H)??5?? methylpyrimidine??2, 4??dion??1??yl]??1, 6??heptadiene via building the pyrimidine ring utilizing 4?? isocyanato??1, 6??heptadiene intermediate.