2, 4-Dihydro-3H-1, 2, 4-triazole-3-thiones as potential antidepressant agents

JM Kane, MW Dudley, SM Sorensen…

Index: Kane, John M.; Dudley, Mark W.; Sorensen, Stephen M.; Miller, Francis P. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1253 - 1258

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Citation Number: 172

Abstract

A series of 5-aryl-2, 4-dihydro-3H-1, 2, 4-triazole-3-thiones was prepared and evaluated for potential antidepressant activity. Members of this series were generally prepared by the alkaline ring closures of the corresponding 1-aroylthiosemicarbazides. Several members of this series were potent antagonists of both RO 4-1284-induced hypothermia and reserpine- induced ptosis in mice. In general the more active members of this series were substituted ...