Synthesis of 2, 4, 6-tripyridyl pyridines, and evaluation of their antitumor cytotoxicity, topoisomerase I and II inhibitory activity, and structure-activity relationship

BS Jeong, HY Choi, YS Kwak…

Index: Jeong, Byeong-Seon; Choi, Hoyoung; Kwak, Young-Shin; Lee, Eung-Seok Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 10 p. 3566 - 3570

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Citation Number: 5

Abstract

Abstract A series of 2, 4, 6-tripyridyl pyridines were synthesized, and evaluated for their antitumor cytotoxicity, topoisomerase I and II inhibitory activity. From the eighteen prepared compounds, compounds 10-12 have shown better or similar cytotoxicity against several human cancer cell lines as compared to 2, 2': 6', 2"-terpyridine and doxorubicin. Especially, compound 10 exhibited the most potent cytotoxicity better than positive controls. Structure- ...