Synthesis and in vitro transdermal penetration enhancing activity of lactam N-acetic acid esters

BB Michniak, MR Player, JW Sowell

Index: Michniak, Bozena B.; Player, Mark R.; Sowell Sr., J. Walter Journal of Pharmaceutical Sciences, 1996 , vol. 85, # 2 p. 150 - 154

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Citation Number: 18

Abstract

Abstract A homologous series of N-acetic acid esters of 2-pyrrolidinone and 2-piperidinone has been prepared and evaluated for its ability to enhance the skin content and flux of hydrocortisone 21-acetate in hairless mouse skin in vitro. Enhancement ratios (ER) were determined for flux (J), 24-hour diffusion cell receptor cell concentrations (Q 24), and 24-h full-thickness mouse skin steroid content (SC) and compared to control values (no ...