Photoirradiation products of flavin derivatives, and the effects of photooxidation on guanine

…, T Kobayashi, E Arima, R Komori, T Kobayashi…

Index: Kino, Katsuhito; Kobayashi, Teruhiko; Arima, Eiji; Komori, Rie; Kobayashi, Takanobu; Miyazawa, Hiroshi Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 7 p. 2070 - 2074

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Citation Number: 18

Abstract

Photoirradiation in the presence of riboflavin led to guanine oxidation and the formation of imidazolone. Meanwhile, riboflavin itself was degraded by ultraviolet light A (UV-A) and visible light (VIS) radiation, and the end product was lumichrome. VIS radiation in the presence of riboflavin oxidized guanine similarly to UV-A radiation. Although UV-A radiation with lumichrome oxidized guanine, VIS radiation with lumichrome did not. Thus, UV-A ...