Medicinal Chemistry Research

Synthesis and antimicrobial activity of pyrazolinones and pyrazoles having benzothiazole moiety

M Amir, SA Javed, MZ Hassan

Index: Amir, Mohd.; Javed, Sadique A.; Hassan, Mohd. Zaheen Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1261 - 1270

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Citation Number: 20

Abstract

Abstract A new class of 4-arylhydrazono-1-benzothiazolyl-3-methylpyrazolin-5-ones (3a–j) and 4-arylazo-1-benzothiazolyl-3, 5-dimethylpyrazoles (4a–j) were designed as pharmacophore hybrids between pyrazolinone/pyrazole and benzothiazole moiety. The target molecules were efficiently synthesized by the cyclization of various oxobutyrates/pentane-2, 4-dione derivatives with 6-chloro-2-hydrazinobenzothiazole in ...