The Journal of Organic Chemistry

Procedures for the acylation of diethyl malonate and ethyl acetoacetate with acid chlorides using tertiary amine bases and magnesium chloride

MW Rathke, PJ Cowan

Index: Rathke, Michael W.; Cowan, Patrick J. Journal of Organic Chemistry, 1985 , vol. 50, # 15 p. 2622 - 2624

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Citation Number: 109

Abstract

In the presence of magnesium chloride and 2 equiv of triethylamine, diethyl malonate is C- acylated in excellent yields by acid chlorides. A variety of other metal chlorides were ineffective. Similarly, ethyl acetoacetate is C-acylated by acid chlorides in the presence of magnesium chloride and 2 equiv of pyridine.