Nucleosides, Nucleotides & Nucleic Acids

O6-(4-Nitrophenyl) inosine and-Guanosine as Chromogenic Substrates for Adenosine Deaminase 1

J Zemlicka, T Endo

Index: Zemlicka, Jiri; Endo, Takeshi Nucleosides and Nucleotides, 1996 , vol. 15, # 1-3 p. 619 - 629

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Citation Number: 2

Abstract

Abstract O6-(4-Nitrophenyl) inosine (la), O6-(4-nitrophenyl) guanosine (1c) and O6-(4- methylumbelliferonyl) inosine (2) were obtained by reaction of 6-chloro-9-(β-D- ribofuranosyl) purine (3a) or 2-amino-6-chloro-9-(β-D-ribofuranosyl) purine (3c) with sodium salts of 4-nitrophenol or 4-methylumbelliferone in N, N-dimethylformamide. Similarly, 6- chloro-9-(β-D-2, 3-isopropylideneribofuranosyl) purine (3b) was transformed to 2′, 3′-O ...