Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry

…, J Wang, M Caffrey, LL Rong, DJ Wardrop

Index: Yermolina, Maria V.; Wang, Jizhen; Caffrey, Michael; Rong, Lijun L.; Wardrop, Duncan J. Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 765 - 781

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Citation Number: 38

Abstract

Herein, we report the development of an antifiloviral screening system, based on a pseudotyping strategy, and its application in the discovery of a novel group of small molecules that selectively inhibit the Ebola and Marburg glycoprotein (GP)-mediated infection of human cells. Using Ebola Zaire GP-pseudotyped HIV particles bearing a luciferase reporter gene and 293T cells, a library of 237 small molecules was screened for ...